The N-Terminal Extension of Cardiac Troponin T Stabilizes the Blocked State of Cardiac Thin Filament

Cardiac troponin T (cTnT) is a key component of contractile regulatory proteins. cTnT is characterized by a ∼32 amino acid N-terminal extension (NTE), the function of which remains unknown. To understand its function, we generated a transgenic (TG) mouse line that expressed a recombinant chimeric cT...

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Bibliographic Details
Main Authors: Gollapudi, Sampath K., Mamidi, Ranganath, Mallampalli, Sri Lakshmi, Chandra, Murali
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2012
Subjects:
Molecular Machines, Motors, and Nanoscale Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433604/
https://ncbi.nlm.nih.gov/pubmed/23009843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.07.035
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