Identification of unique MEK-dependent genes in GNAQ mutant uveal melanoma involved in cell growth, tumor cell invasion and MEK-resistance.

PURPOSE: Metastatic uveal melanoma (UM) represents the most common intraocular malignancy with very poor prognosis and no effective treatments. Oncogenic mutations in the G protein alpha subunit q and 11 have been described in about 85% of uveal melanomas and confer constitutive activation. Multiple...

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Bibliographic Details
Main Authors: Ambrosini, Grazia, Pratilas, Christine A., Qin, Li-Xuan, Tadi, Madhavi, Surriga, Oliver, Carvajal, Richard D., Schwartz, Gary K.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433236/
https://ncbi.nlm.nih.gov/pubmed/22550165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-3086
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