Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers

Successful immunity requires that a limited pool of αβ T-cell receptors (TCRs) provide cover for a vast number of potential foreign peptide antigens presented by ‘self’ major histocompatibility complex (pMHC) molecules. Structures of unligated and ligated MHC class-I-restricted TCRs with different l...

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Hauptverfasser: Holland, Christopher J., Rizkallah, Pierre J., Vollers, Sabrina, Calvo-Calle, J. Mauricio, Madura, Florian, Fuller, Anna, Sewell, Andrew K., Stern, Lawrence J., Godkin, Andrew, Cole, David K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432979/
https://ncbi.nlm.nih.gov/pubmed/22953050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00629
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