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Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers
Successful immunity requires that a limited pool of αβ T-cell receptors (TCRs) provide cover for a vast number of potential foreign peptide antigens presented by ‘self’ major histocompatibility complex (pMHC) molecules. Structures of unligated and ligated MHC class-I-restricted TCRs with different l...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3432979/ https://ncbi.nlm.nih.gov/pubmed/22953050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00629 |
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