Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3

Anterior-posterior (AP) limb patterning is directed by sonic hedgehog (SHH) signaling from the posteriorly located Zone of Polarizing Activity (ZPA). GLI3 and GLI2 are the transcriptional mediators generally utilized in SHH signaling, and each can function as an activator (A) and repressor (R). Alth...

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Main Authors: Bowers, Megan, Eng, Liane, Lao, Zhimin, Turnbull, Rowena K., Bao, Xiaozhong, Riedel, Elyn, Mackem, Susan, Joyner, Alexandra L.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432687/
https://ncbi.nlm.nih.gov/pubmed/22841643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2012.07.017
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