Gata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb Development

Gli3 is a major regulator of Hedgehog signaling during limb development. In the anterior mesenchyme, GLI3 is proteolytically processed into GLI3R, a truncated repressor form that inhibits Hedgehog signaling. Although numerous studies have identified mechanisms that regulate Gli3 function in vitro, i...

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Pubblicato in:PLoS Genet
Autori principali: Hayashi, Shinichi, Akiyama, Ryutaro, Wong, Julia, Tahara, Naoyuki, Kawakami, Hiroko, Kawakami, Yasuhiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924869/
https://ncbi.nlm.nih.gov/pubmed/27352137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006138
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