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Mouse limbs expressing only the Gli3 repressor resemble those of Sonic Hedgehog mutants
Anterioposterior vertebrate limb patterning is controlled by opposing action between Sonic Hedgehog (Shh) and the Gli3 transcriptional repressor. Unexpectedly, Gli3(Δ699) mutant mice, which are thought to express only a Gli3 repressor and not the full-length activator, exhibit limb phenotypes incons...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3707282/ https://ncbi.nlm.nih.gov/pubmed/23644062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2013.04.025 |
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