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Alternative mitochondrial fuel extends lifespan
In this issue, Ristow and colleagues elucidate a conserved mechanism through whichreduced insulin-IGF1 signaling activates an AMP-kinase driven metabolic shift towards oxidative proline metabolism that produces an adaptive mitochondrial ROS signal to extend worm lifespan. These findings further bols...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3432500/ https://ncbi.nlm.nih.gov/pubmed/22482723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.03.011 |
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