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A p27(Kip1) mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation
Mitotic catastrophe occurs when cells enter mitosis with damaged DNA or excess centrosomes. Cells overexpressing the centrosome protein CP110 or depleted of cyclin F, which targets CP110 for destruction, have more than two centrosomes and undergo mitotic catastrophe. Our studies show centrosome redu...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3432229/ https://ncbi.nlm.nih.gov/pubmed/22158041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.550 |
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