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The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin()
Hymeglusin (1233A; F244; L-659-699) is established as a specific beta lactone inhibitor of eukaryotic hydroxymethylglutaryl-CoA synthase (HMGCS). Inhibition results from formation of a thioester adduct to the active site cysteine. In contrast, hymeglusin’s effects on bacterial HMG-CoA synthase, mvaS...
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| Main Authors: | , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2012
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3431454/ https://ncbi.nlm.nih.gov/pubmed/22510038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300037k |
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