Crystal Structures of Staphylococcus epidermidis Mevalonate Diphosphate Decarboxylase Bound to Inhibitory Analogs Reveal New Insight into Substrate Binding and Catalysis

The polyisoprenoid compound undecaprenyl phosphate is required for biosynthesis of cell wall peptidoglycans in Gram-positive bacteria, including pathogenic Enterococcus, Streptococcus, and Staphylococcus spp. In these organisms, the mevalonate pathway is used to produce the precursor isoprenoid, iso...

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Detalhes bibliográficos
Main Authors: Barta, Michael L., Skaff, D. Andrew, McWhorter, William J., Herdendorf, Timothy J., Miziorko, Henry M., Geisbrecht, Brian V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129171/
https://ncbi.nlm.nih.gov/pubmed/21561869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.242016
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