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Functional Insights into Human HMG-CoA Lyase from Structures of Acyl-CoA-containing Ternary Complexes
HMG-CoA lyase (HMGCL) is crucial to ketogenesis, and inherited human mutations are potentially lethal. Detailed understanding of the HMGCL reaction mechanism and the molecular basis for correlating human mutations with enzyme deficiency have been limited by the lack of structural information for enz...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924059/ https://ncbi.nlm.nih.gov/pubmed/20558737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.139931 |
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