Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency–Associated Developmental Defects by Preventing Matriptase Activation

Loss of either hepatocyte growth factor activator inhibitor (HAI)-1 or -2 is associated with embryonic lethality in mice, which can be rescued by the simultaneous inactivation of the membrane-anchored serine protease, matriptase, thereby demonstrating that a matriptase-dependent proteolytic pathway...

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Autores principales: Szabo, Roman, Uzzun Sales, Katiuchia, Kosa, Peter, Shylo, Natalia A., Godiksen, Sine, Hansen, Karina K., Friis, Stine, Gutkind, J. Silvio, Vogel, Lotte K., Hummler, Edith, Camerer, Eric, Bugge, Thomas H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431340/
https://ncbi.nlm.nih.gov/pubmed/22952456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002937
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