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Potent and Selective Synthetic Modulators of a Quorum Sensing Repressor in Pseudomonas aeruginosa Identified from Second-Generation Libraries of N-Acylated l-Homoserine Lactones

Bacteria can coordinate group behavior using chemical signals in a process called quorum sensing (QS). The QS system in the opportunistic pathogen Pseudomonas aeruginosa is largely governed by the LasR receptor and its cognate chemical signal, N-(3-oxo)-dodecanoyl l-homoserine lactone (OdDHL). LasR...

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Autores principales: Mattmann, Margrith E., Shipway, Patrick M., Heth, Nicole J., Blackwell, Helen E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431017/
https://ncbi.nlm.nih.gov/pubmed/21365734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201000708
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