Gabapentin’s minimal action on markers of rat brain arachidonic acid metabolism agrees with its inefficacy against bipolar disorder

In rats, FDA-approved mood stabilizers used for treating bipolar disorder (BD) selectively downregulate brain markers of the arachidonic acid (AA) cascade, which are upregulated in postmortem BD brain. Phase III clinical trials show that gabapentin (GBP) is ineffective in treating BD. We hypothesize...

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Main Authors: Reese, Edmund A., Cheon, Yewon, Ramadan, Epolia, Kim, Hyung-Wook, Chang, Lisa, Rao, Jagadeesh S., Rapoport, Stanley I., Taha, Ameer Y.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431015/
https://ncbi.nlm.nih.gov/pubmed/22841517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.plefa.2012.06.003
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