ATM and MET kinases are synthetic lethal with non-genotoxic activation of p53

The p53 tumor suppressor orchestrates alternative stress responses including cell cycle arrest and apoptosis, but the mechanisms defining cell fate upon p53 activation are poorly understood. Several small molecule activators of p53 have been developed, including Nutlin-3, but their therapeutic poten...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Sullivan, Kelly D., Padilla-Just, Nuria, Henry, Ryan E., Porter, Christopher C., Kim, Jihye, Tentler, John J., Eckhardt, S. Gail, Tan, Aik Choon, DeGregori, James, Espinosa, Joaquín M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430605/
https://ncbi.nlm.nih.gov/pubmed/22660439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.965
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы