Role of Endoplasmic Reticulum Aminopeptidases in Health and Disease: from Infection to Cancer

Endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 (ERAPs) are essential for the maturation of a wide spectrum of proteins involved in various biological processes. In the ER, these enzymes work in concert to trim peptides for presentation on MHC class I molecules. Loss of ERAPs function sub...

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Bibliographic Details
Main Authors: Cifaldi, Loredana, Romania, Paolo, Lorenzi, Silvia, Locatelli, Franco, Fruci, Doriana
Format: Artigo
Language:Inglês
Published: Molecular Diversity Preservation International (MDPI) 2012
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430237/
https://ncbi.nlm.nih.gov/pubmed/22942706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms13078338
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