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The Hypersensitive Glucocorticoid Response Specifically Regulates Period 1 and Expression of Circadian Genes

Glucocorticoids regulate gene expression by binding and activating the glucocorticoid receptor (GR). While ligand affinity determines the global sensitivity of the response, additional proteins act on the genome to tune sensitivity of some genes. However, the genomic extent and specificity of dose-s...

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Main Authors: Reddy, Timothy E., Gertz, Jason, Crawford, Gregory E., Garabedian, Michael J., Myers, Richard M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3430195/
https://ncbi.nlm.nih.gov/pubmed/22801371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00062-12
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