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Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation

The glucocorticoid steroid hormone cortisol is released by the adrenal glands in response to stress and serves as a messenger in circadian rhythms. Transcriptional responses to this hormonal signal are mediated by the glucocorticoid receptor (GR). We determined GR binding throughout the human genome...

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Bibliografiske detaljer
Main Authors: Reddy, Timothy E., Pauli, Florencia, Sprouse, Rebekka O., Neff, Norma F., Newberry, Kimberly M., Garabedian, Michael J., Myers, Richard M.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792167/
https://ncbi.nlm.nih.gov/pubmed/19801529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.097022.109
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