Cleavage of Nidogen-1 by Cathepsin S Impairs Its Binding to Basement Membrane Partners

Cathepsin S (catS), which is expressed in normal human keratinocytes and localized close to the dermal-epidermal junction (DEJ) degrades some of major basement membrane (BM) constituents. Among them, catS readily hydrolyzed in a time and dose dependent manner human nidogen-1 (nid-1) and nidogen-2, w...

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Main Authors: Sage, Juliette, Leblanc-Noblesse, Emmanuelle, Nizard, Carine, Sasaki, Takako, Schnebert, Sylvianne, Perrier, Eric, Kurfurst, Robin, Brömme, Dieter, Lalmanach, Gilles, Lecaille, Fabien
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429489/
https://ncbi.nlm.nih.gov/pubmed/22952693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043494
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