IL-22 Signaling Contributes to West Nile Encephalitis Pathogenesis

The Th17 cytokine, IL-22, regulates host immune responses to extracellular pathogens. Whether IL-22 plays a role in viral infection, however, is poorly understood. We report here that Il22(−/−) mice were more resistant to lethal West Nile virus (WNV) encephalitis, but had similar viral loads in the...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Wang, Penghua, Bai, Fengwei, Zenewicz, Lauren A., Dai, Jianfeng, Gate, David, Cheng, Gong, Yang, Long, Qian, Feng, Yuan, Xiaoling, Montgomery, Ruth R., Flavell, Richard A., Town, Terrence, Fikrig, Erol
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429482/
https://ncbi.nlm.nih.gov/pubmed/22952908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044153
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