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Role of Self-Tolerance and Chronic Stimulation in the Long-Term Persistence of Adenovirus-Induced Thyrotropin Receptor Antibodies in Wild-Type and Transgenic Mice

BACKGROUND: Graves'-like disease, reflected by thyrotropin receptor (TSHR) antibodies and hyperthyroidism in some mouse strains, can be induced by immunization with adenovirus-expressing DNA for the human TSHR or its A-subunit. The conventional approach involves two or three adenovirus injectio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: McLachlan, Sandra M., Aliesky, Holly A., Chen, Chun-Rong, Rapoport, Basil
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429281/
https://ncbi.nlm.nih.gov/pubmed/22827528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2012.0008
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