Pharmacogenomic profiling and pathway analyses identify MAPK-dependent migration as an acute response to SN38 in p53 null and mutant colorectal cancer cells

The topoisomerase I inhibitor irinotecan is used to treat advanced colorectal cancer and has been shown to have p53-independent anti-cancer activity. The aim of this study was to identify the p53-independent signalling mechanisms activated by irinotecan. Transcriptional profiling of isogenic HCT116...

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Bibliografiske detaljer
Main Authors: Allen, Wendy L., Turkington, Richard C., Stevenson, Leanne, Carson, Gail, Coyle, Vicky M., Hector, Suzanne, Dunne, Philip, Van Schaeybroeck, Sandra, Longley, Daniel B., Johnston, Patrick G.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428848/
https://ncbi.nlm.nih.gov/pubmed/22665525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0207
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