Rapid deconjugation of SN-38 glucuronide and adsorption of released free SN-38 by intestinal microorganisms in rat

One of the dose-limiting toxicities of irinotecan hydrochloride (CPT-11) is delayed-onset diarrhea. CPT-11 is converted to its active metabolite, SN-38, which is conjugated to SN-38 glucuronide (SN-38G). SN-38G excreted in the intestinal lumen is extensively deconjugated by bacterial β-glucuronidase...

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Main Authors: TAKAKURA, AKIRA, KURITA, AKINOBU, ASAHARA, TAKASHI, YOKOBA, MASANORI, YAMAMOTO, MICHIKO, RYUGE, SHINICHIRO, IGAWA, SATOSHI, YASUZAWA, YUKITOSHI, SASAKI, JIICHIRO, KOBAYASHI, HIROSUKE, MASUDA, NORIYUKI
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362476/
https://ncbi.nlm.nih.gov/pubmed/22740943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2011.519
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