MRKAd5 HIV-1 Gag/Pol/Nef Vaccine-Induced T-Cell Responses Inadequately Predict Distance of Breakthrough HIV-1 Sequences to the Vaccine or Viral Load

BACKGROUND: The sieve analysis for the Step trial found evidence that breakthrough HIV-1 sequences for MRKAd5/HIV-1 Gag/Pol/Nef vaccine recipients were more divergent from the vaccine insert than placebo sequences in regions with predicted epitopes. We linked the viral sequence data with immune resp...

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Autores principales: Janes, Holly, Frahm, Nicole, DeCamp, Allan, Rolland, Morgane, Gabriel, Erin, Wolfson, Julian, Hertz, Tomer, Kallas, Esper, Goepfert, Paul, Friedrich, David P., Corey, Lawrence, Mullins, James I., McElrath, M. Juliana, Gilbert, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428369/
https://ncbi.nlm.nih.gov/pubmed/22952672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043396
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