Genetic impact of vaccination on breakthrough HIV-1 sequences from the Step trial

We analyzed HIV-1 genome sequences from 68 newly-infected volunteers in the Step HIV-1 vaccine trial. To determine whether the vaccine exerted selective T-cell pressure on breakthrough viruses, we identified potential T-cell epitopes in the founder sequences and compared them to epitopes in the vacc...

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Detalhes bibliográficos
Main Authors: Rolland, Morgane, Tovanabutra, Sodsai, deCamp, Allan C., Frahm, Nicole, Gilbert, Peter B., Sanders-Buell, Eric, Heath, Laura, Magaret, Craig A., Bose, Meera, Bradfield, Andrea, O’Sullivan, Annemarie, Crossler, Jacqueline, Jones, Teresa, Nau, Marty, Wong, Kim, Zhao, Hong, Raugi, Dana N., Sorensen, Stephanie, Stoddard, Julia N., Maust, Brandon S., Deng, Wenjie, Hural, John, Dubey, Sheri, Michael, Nelson L., Shiver, John, Corey, Lawrence, Li, Fusheng, Self, Steve G., Kim, Jerome, Buchbinder, Susan, Casimiro, Danilo R., Robertson, Michael N., Duerr, Ann, McElrath, M. Juliana, McCutchan, Francine E., Mullins, James I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053571/
https://ncbi.nlm.nih.gov/pubmed/21358627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2316
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