A study of vaccine-induced immune pressure on breakthrough infections in the Phambili phase 2b HIV-1 vaccine efficacy trial

INTRODUCTION: The Merck Adenovirus-5 Gag/Pol/Nef HIV-1 subtype-B vaccine evaluated in predominately subtype B epidemic regions (Step Study), while not preventing infection, exerted vaccine-induced immune pressure on HIV-1 breakthrough infections. Here we investigated if the same vaccine exerted immu...

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Gepubliceerd in:Vaccine
Hoofdauteurs: Hertz, T., Logan, M.G., Rolland, M., Magaret, C.A., Rademeyer, C., Fiore-Gartland, A., Edlefsen, P.T., DeCamp, A., Ahmed, H., Ngandu, N., Larsen, B.B., Frahm, N., Marais, J., Thebus, R., Geraghty, D., Hural, J., Corey, L., Kublin, J., Gray, G., McElrath, M.J., Mullins, J.I., Gilbert, P.B., Williamson, C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309337/
https://ncbi.nlm.nih.gov/pubmed/27756485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2016.09.054
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