Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

The chemokine receptor CXCR2 is a key mediator of neutrophil migration that also plays a role in tumor development. However, CXCR2 influences tumors through multiple mechanisms and might promote or inhibit tumor development depending on context. Here, we used several mouse models of spontaneous and...

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Autori principali: Jamieson, Thomas, Clarke, Mairi, Steele, Colin W., Samuel, Michael S., Neumann, Jens, Jung, Andreas, Huels, David, Olson, Michael F., Das, Sudipto, Nibbs, Robert J.B., Sansom, Owen J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428079/
https://ncbi.nlm.nih.gov/pubmed/22922255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61067
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