CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

CXCR2 has been suggested to have both tumor-promoting and tumor-suppressive properties. Here we show that CXCR2 signaling is upregulated in human pancreatic cancer, predominantly in neutrophil/myeloid-derived suppressor cells, but rarely in tumor cells. Genetic ablation or inhibition of CXCR2 abroga...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cancer Cell
Main Authors: Steele, Colin W., Karim, Saadia A., Leach, Joshua D.G., Bailey, Peter, Upstill-Goddard, Rosanna, Rishi, Loveena, Foth, Mona, Bryson, Sheila, McDaid, Karen, Wilson, Zena, Eberlein, Catherine, Candido, Juliana B., Clarke, Mairi, Nixon, Colin, Connelly, John, Jamieson, Nigel, Carter, C. Ross, Balkwill, Frances, Chang, David K., Evans, T.R. Jeffry, Strathdee, Douglas, Biankin, Andrew V., Nibbs, Robert J.B., Barry, Simon T., Sansom, Owen J., Morton, Jennifer P.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912354/
https://ncbi.nlm.nih.gov/pubmed/27265504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.04.014
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker