FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice

Breast cancers commonly become resistant to EGFR–tyrosine kinase inhibitors (EGFR-TKIs); however, the mechanisms of this resistance remain largely unknown. We hypothesized that resistance may originate, at least in part, from molecular alterations that activate signaling downstream of EGFR. Using a...

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Bibliografiske detaljer
Main Authors: Lee, Sun-Young, Meier, Roland, Furuta, Saori, Lenburg, Marc E., Kenny, Paraic A., Xu, Ren, Bissell, Mina J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428077/
https://ncbi.nlm.nih.gov/pubmed/22886303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60498
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