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Targeting TACE-dependent EGFR ligand shedding in breast cancer

The ability to proliferate independently of signals from other cell types is a fundamental characteristic of tumor cells. Using a 3D culture model of human breast cancer progression, we have delineated a protease-dependent autocrine loop that provides an oncogenic stimulus in the absence of proto-on...

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Detalles Bibliográficos
Main Authors: Kenny, Paraic A., Bissell, Mina J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2007
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1764856/
https://ncbi.nlm.nih.gov/pubmed/17218988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29518
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