PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors

The genetic evolution from a benign neurofibroma to a malignant sarcoma in patients with neurofibromatosis type 1 (NF1) syndrome remains unclear. Schwann cells and/or their precursor cells are believed to be the primary pathogenic cell in neurofibromas because they harbor biallelic neurofibromin 1 (...

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Main Authors: Keng, Vincent W., Rahrmann, Eric P., Watson, Adrienne L., Tschida, Barbara R., Moertel, Christopher L., Jessen, Walter J., Rizvi, Tilat A., Collins, Margaret H., Ratner, Nancy, Largaespada, David A.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428071/
https://ncbi.nlm.nih.gov/pubmed/22700876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-4092
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