Insulin-containing lipogenic stimuli suppress mast cell degranulation potential and up-regulate lipid body biogenesis and eicosanoid secretion in a PPARγ-independent manner

Lipid bodies are most studied in adipocytes, where the lipogenic action of insulin initiates their formation. Here, we test the hypothesis that insulin may regulate lipid body content in mast cells and hence, modify their proinflammatory potential. Our data show that insulin causes lipid body accumu...

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Bibliographische Detailangaben
Hauptverfasser: Greineisen, William E., Shimoda, Lori M. N., Maaetoft-Udsen, Kristina, Turner, Helen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Leukocyte Biology 2012
Schlagworte:
Inflammation, Extracellular Mediators, & Effector Molecules
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427608/
https://ncbi.nlm.nih.gov/pubmed/22706316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0811406
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