Chronic Insulin Exposure Induces ER Stress and Lipid Body Accumulation in Mast Cells at the Expense of Their Secretory Degranulation Response

Lipid bodies (LB) are reservoirs of precursors to inflammatory lipid mediators in immunocytes, including mast cells. LB numbers are dynamic, increasing dramatically under conditions of immunological challenge. We have previously shown in vitro that insulin-influenced lipogenic pathways induce LB bio...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Greineisen, William E., Maaetoft-Udsen, Kristina, Speck, Mark, Balajadia, Januaria, Shimoda, Lori M. N., Sung, Carl, Turner, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532411/
https://ncbi.nlm.nih.gov/pubmed/26263026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130198
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