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Structures of YAP protein domains reveal promising targets for development of new cancer drugs
YAP (Yes-associated protein) is a potent oncogene and a major effector of the mammalian Hippo tumor suppressor pathway. In this review, our emphasis is on the structural basis of how YAP recognizes its various cellular partners. In particular, we discuss the role of LATS kinase and AMOTL1 junction p...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427467/ https://ncbi.nlm.nih.gov/pubmed/22609812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2012.05.002 |
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