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Screen Anti-influenza Lead Compounds That Target the PA(C) Subunit of H5N1 Viral RNA Polymerase

The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the desig...

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Detalhes bibliográficos
Main Authors: Li, Lin, Chang, Shenghai, Xiang, Junfeng, Li, Qian, Liang, Huanhuan, Tang, Yalin, Liu, Yingfang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427309/
https://ncbi.nlm.nih.gov/pubmed/22936968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035234
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