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HDAC6 Restricts Influenza A Virus by Deacetylation of the RNA Polymerase PA Subunit

The life cycle of influenza A virus (IAV) is modulated by various cellular host factors. Although previous studies indicated that IAV infection is controlled by HDAC6, the deacetylase involved in the regulation of PA remained unknown. Here, we demonstrate that HDAC6 acts as a negative regulator of I...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Chen, Huan, Qian, Yingjuan, Chen, Xin, Ruan, Zhiyang, Ye, Yuetian, Chen, Hongjun, Babiuk, Lorne A., Jung, Yong-Sam, Dai, Jianjun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364008/
https://ncbi.nlm.nih.gov/pubmed/30518648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01896-18
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