The Replication Activity of Influenza Virus Polymerase Is Linked to the Capacity of the PA Subunit To Induce Proteolysis

The PA subunit of the influenza virus polymerase complex is a phosphorylated protein that induces a proteolytic process that decreases its own accumulation levels and those of coexpressed proteins. The amino-terminal third of the protein is responsible for the induction of proteolysis. We mutated fi...

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Autores principales: Perales, Beatriz, Sanz-Ezquerro, Juan J., Gastaminza, Pablo, Ortega, Joaquin, Santarén, Juan Férnandez, Ortín, Juan, Nieto, Amelia
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC111465/
https://ncbi.nlm.nih.gov/pubmed/10627541
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