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The Replication Activity of Influenza Virus Polymerase Is Linked to the Capacity of the PA Subunit To Induce Proteolysis

The PA subunit of the influenza virus polymerase complex is a phosphorylated protein that induces a proteolytic process that decreases its own accumulation levels and those of coexpressed proteins. The amino-terminal third of the protein is responsible for the induction of proteolysis. We mutated fi...

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Published in:J Virol
Main Authors: Perales, Beatriz, Sanz-Ezquerro, Juan J., Gastaminza, Pablo, Ortega, Joaquin, Santarén, Juan Férnandez, Ortín, Juan, Nieto, Amelia
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2000
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111465/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10627541/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.3.1307-1312.2000
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