Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development

To study the role of the diphthamide modification on eukaryotic elongation factor 2 (eEF2), we generated an eEF2 Gly(717)Arg mutant mouse, in which the first step of diphthamide biosynthesis is prevented. Interestingly, the Gly(717)-to-Arg mutation partially compensates the eEF2 functional loss resu...

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Detalhes bibliográficos
Main Authors: Liu, Shihui, Bachran, Christopher, Gupta, Pradeep, Miller-Randolph, Sharmina, Wang, Hailun, Crown, Devorah, Zhang, Yi, Wein, Alexander N., Singh, Rajat, Fattah, Rasem, Leppla, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427129/
https://ncbi.nlm.nih.gov/pubmed/22869748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206933109
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