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Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis
Vertebrate Hedgehog (Hh) signals involved in development and some forms of cancer, such as basal cell carcinoma, are transduced by the primary cilium, a microtubular projection found on many cells. A critical step in vertebrate Hh signal transduction is the regulated movement of Smoothened (Smo), a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427101/ https://ncbi.nlm.nih.gov/pubmed/22864913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207170109 |
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