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Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis

Vertebrate Hedgehog (Hh) signals involved in development and some forms of cancer, such as basal cell carcinoma, are transduced by the primary cilium, a microtubular projection found on many cells. A critical step in vertebrate Hh signal transduction is the regulated movement of Smoothened (Smo), a...

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Autori principali: Wu, Victoria M., Chen, Steven C., Arkin, Michelle R., Reiter, Jeremy F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427101/
https://ncbi.nlm.nih.gov/pubmed/22864913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207170109
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