ERK1/2 activation is a therapeutic target in age-related macular degeneration

Deficient expression of the RNase III DICER1, which leads to the accumulation of cytotoxic Alu RNA, has been implicated in degeneration of the retinal pigmented epithelium (RPE) in geographic atrophy (GA), a late stage of age-related macular degeneration that causes blindness in millions of people w...

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Main Authors: Dridi, Sami, Hirano, Yoshio, Tarallo, Valeria, Kim, Younghee, Fowler, Benjamin J., Ambati, Balamurali K., Bogdanovich, Sasha, Chiodo, Vince A., Hauswirth, William W., Kugel, Jennifer F., Goodrich, James A., Ponicsan, Steven L., Hinton, David R., Kleinman, Mark E., Baffi, Judit Z., Gelfand, Bradley D., Ambati, Jayakrishna
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2012
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427082/
https://ncbi.nlm.nih.gov/pubmed/22869729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206494109
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