ERK1/2 activation is a therapeutic target in age-related macular degeneration

Deficient expression of the RNase III DICER1, which leads to the accumulation of cytotoxic Alu RNA, has been implicated in degeneration of the retinal pigmented epithelium (RPE) in geographic atrophy (GA), a late stage of age-related macular degeneration that causes blindness in millions of people w...

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Detalhes bibliográficos
Main Authors: Dridi, Sami, Hirano, Yoshio, Tarallo, Valeria, Kim, Younghee, Fowler, Benjamin J., Ambati, Balamurali K., Bogdanovich, Sasha, Chiodo, Vince A., Hauswirth, William W., Kugel, Jennifer F., Goodrich, James A., Ponicsan, Steven L., Hinton, David R., Kleinman, Mark E., Baffi, Judit Z., Gelfand, Bradley D., Ambati, Jayakrishna
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427082/
https://ncbi.nlm.nih.gov/pubmed/22869729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206494109
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