IgG1(+) ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells

We used somatic cell nuclear transfer (SCNT) to generate a mouse from the nucleus of an IgG1(+) ovalbumin-specific B cell. The resulting OBI mice show generally normal B-cell development, with elevated percentages of marginal zone B cells and a reduction in B-1 B cells. Whereas OBI RAG1(−/−) mice ha...

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Detaylı Bibliyografya
Asıl Yazarlar: Dougan, Stephanie K., Ogata, Souichi, Hu, Chih-Chi Andrew, Grotenbreg, Gijsbert M., Guillen, Eduardo, Jaenisch, Rudolf, Ploegh, Hidde L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2012
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427072/
https://ncbi.nlm.nih.gov/pubmed/22869725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210273109
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