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Coxsackievirus B3 mutator strains are attenuated in vivo
Based on structural data of the RNA-dependent RNA polymerase, rational targeting of key residues, and screens for Coxsackievirus B3 fidelity variants, we isolated nine polymerase variants with mutator phenotypes, which allowed us to probe the effects of lowering fidelity on virus replication, mutabi...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427060/ https://ncbi.nlm.nih.gov/pubmed/22853955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204022109 |
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