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Effect of Chelator Conjugation Level and Injection Dose on Tumor and Organ Uptake of (111)In Labeled MORAb-009, an Anti-mesothelin Antibody
INTRODUCTION: Radiolabeling of a monoclonal antibody (mAb) with a metallic radionuclide requires the conjugation of a bifunctional chelator to the mAb. The conjugation, however, can alter the physical and immunological properties of the mAb, consequently affecting its tumor targeting pharmacokinetic...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3426867/ https://ncbi.nlm.nih.gov/pubmed/21741258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2011.05.003 |
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