Selective reduction in the sphingomyelin content of atherogenic lipoproteins inhibits their retention in murine aortas and the subsequent development of atherosclerosis

OBJECTIVE: The sphingolipid de novo synthesis pathway is considered a promising target for pharmacological intervention in atherosclerosis. However, its potential is hampered by the fact that the substance’s atherogenic mechanism is not completely understood. To unravel the complex mechanisms, we ut...

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Main Authors: Fan, Yifan, Shi, Fujun, Liu, Jing, Dong, Jibin, Bui, Hai H., Peake, David A., Kuo, Ming-Shang, Cao, Guoqing, Jiang, Xian-Cheng
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426833/
https://ncbi.nlm.nih.gov/pubmed/20814016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.213363
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