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The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum
BACKGROUND: Lumefantrine and atovaquone are highly lipophilic anti-malarial drugs. As a consequence absorption is increased when the drugs are taken together with a fatty meal, but the free fraction of active drug decreases in the presence of triglyceride-rich plasma lipoproteins. In this study, the...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
BioMed Central
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3426466/ https://ncbi.nlm.nih.gov/pubmed/22640826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-11-177 |
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