Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes

In severe falciparum malaria cytoadherence of parasitised red blood cells (PRBCs) to vascular endothelium (causing sequestration) and to uninfected red cells (causing rosette formation) contribute to microcirculatory flow obstruction in vital organs. Heparin can reverse the underlying ligand-recepto...

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Published in:PLoS One
Main Authors: Saiwaew, Somporn, Sritabal, Juntima, Piaraksa, Nattaporn, Keayarsa, Srisuda, Ruengweerayut, Ronnatrai, Utaisin, Chirapong, Sila, Patima, Niramis, Rangsan, Udomsangpetch, Rachanee, Charunwatthana, Prakaykaew, Pongponratn, Emsri, Pukrittayakamee, Sasithon, Leitgeb, Anna M., Wahlgren, Mats, Lee, Sue J., Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M., Chotivanich, Kesinee
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332063/
https://ncbi.nlm.nih.gov/pubmed/28249043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172718
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