Inhibition of merozoite invasion and transient de-sequestration by sevuparin in humans with Plasmodium falciparum malaria

SEVERE MALARIA: Even with the best available treatment, the mortality from severe Plasmodium falciparum malaria remains high. Typical features at death are high parasite loads and obstructed micro- vasculature. Infected erythrocytes (IE) containing mature parasites bind to the host receptor heparan...

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Veröffentlicht in:PLoS One
Hauptverfasser: Leitgeb, Anna M., Charunwatthana, Prakaykaew, Rueangveerayut, Ronnatrai, Uthaisin, Chirapong, Silamut, Kamolrat, Chotivanich, Kesinee, Sila, Patima, Moll, Kirsten, Lee, Sue J., Lindgren, Maria, Holmer, Erik, Färnert, Anna, Kiwuwa, Mpungu S., Kristensen, Jens, Herder, Christina, Tarning, Joel, Wahlgren, Mats, Dondorp, Arjen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731734/
https://ncbi.nlm.nih.gov/pubmed/29244851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188754
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